科研之友
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摘要
The effect of unilateral nephrectomy on the cardiovascular risk profile of living kidney donors has not been prospectively studied. We performed an observational cohort study of 58 living donors to 6 months postdonation for changes in 24-hr ambulatory blood pressure profiles, renal function, urine protein excretion, body mass index, glucose tolerance, and fasting lipid profiles. The 24-hr systolic blood pressure average and night-day ratio were unchanged from pre- to postdonation (118.9 +/- 11 vs. 118.1 +/- 14 mm Fig, P=0.77; 0.87 +/- 0.07 vs. 0.87 +/- 0.09, P=0.68, respectively). Estimated glomerular filtration rate declined from 91.9 +/- 16 to 61.6 +/- 12 mL/min/1.73 m(2) (P<0.0001). Protein excretion, body mass index, glucose, and lipids were unchanged. No significant differences were noted between dippers and nondippers either pre- or postdonation. In summary, living kidney donation in the short term is safe. We suggest further observation of individuals with lower glomerular filtration rate for possible increased cardiovascular risk factors in the future.
- 出版日期2008-11-15
