Does IL28B genotyping still have a role in the era of direct-acting antiviral therapy for chronic hepatitis C infection?

作者：Holmes J A; Desmond P V; Thompson A J^*

来源：Journal of Viral Hepatitis, 2012, 19(10): 677-684.

DOI：10.1111/jvh.12003

• hepatitis C virus
• IL28B polymoprhism
• NS3 protease
• NS5a protein
• NS5b polymerase
• sustained virological response

IL28B genotype has been shown to be the strongest pretreatment predictor of sustained virological response (SVR) in patients with genotype 1 chronic hepatitis C infection (CHC) treated with pegylated interferon (peg-IFN) and ribavirin (RBV). Patients carrying the good response genotype have a two- to threefold higher chance of SVR than those with a poor response genotype, manifest as dramatically improved early viral kinetics. However, the treatment paradigm for CHC is changing with the introduction of potent direct-acting antivirals (DAAs). IL28B genotype remains relevant to both telaprevir and boceprevir treatment regimens, although the strength of association with virological response is attenuated. The association between IL28B genotype and outcomes of treatment regimens that involve peg-IFN plus combination DAA therapy, or IFN-free regimens, is currently being evaluated. IL28B genotype may remain relevant to individualizing the choice of treatment regimen in the future.

• 出版日期2012-10