A Facile Synthesis of 2-Aminobenzoxazoles and 2-Aminobenzimidazoles Using N-Cyano-N-phenyl-p-toluenesulfonamide (NCTS) as an Efficient Electrophilic Cyanating Agent

作者：Kasthuri Mahesh^*; Babu H Sharath; Kumar K Shiva; Sudhakar Ch; Kumar P V Nagendra

来源：Synlett, 2015, 26(7): 897-900.

DOI：10.1055/s-0034-1380166

• 2-aminobenzoxazoles
• 2-aminobenzimidazoles
• electrophilic cynating agent
• nonhazardous
• N-cyano-N-phenyl-p-toluenesulfonamide

A facile synthesis of 2-aminobenzoxazole and 2-aminobenzimidazole derivatives employing a nonhazardous electrophilic cyanating agent: N-cyano-N-phenyl-p-toluenesulfonamide (NCTS) with various substituted 2-aminophenols and benzene-1,2-diamine derivatives in the presence of lithium hexamethyldisilazide (LiHMDS) is described. This novel protocol boasts operational simplicity, shorter reaction time, and simple workup.

• 出版日期2015-4