科研之友
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摘要
A mitochondria-targeting ratiometric probe was designed for gamma-glutamyltranspeptidase (gamma GT). Mechanistic study by HPLC and an inhibitor assay showed that the probe underwent gamma GT-mediated amide-to-amine transformation and induced a ratiometric fluorescence response in cellular mitochondria. Further application was successful for the detection of cancerous colons in mice.
- 出版日期2016
