Dietary arginine silicate inositol complex increased bone healing: histologic and histomorphometric study

作者：Yaman Ferhan^*; Acikan Izzet; Dundar Serkan; Simsek Sercan; Gul Mehmet; Ozercan Ibrahim Hanifi; Komorowski James; Sahin Kazim

来源：Drug Design, Development and Therapy, 2016, 10: 2081-2086.

DOI：10.2147/DDDT.S109271

• arginine silicate inositol
• bone healing
• osteoblast
• osteoclast
• critical-sized defect

Background: Arginine silicate inositol complex (ASI; arginine 49.5%, silicon 8.2%, and inositol 25%) is a novel material that is a bioavailable source of silicon and arginine. ASI offers potential benefits for vascular and bone health.
Objective: The aim of this study was to evaluate the potential effects of ASI complex on bone healing of critical-sized defects in rats.
Methods: The rats were randomly assigned to two groups of 21 rats each. The control group was fed a standard diet for 12 weeks; after the first 8 weeks, a calvarial critical-sized defect was created, and the rats were sacrificed 7, 14, and 28 days later. The ASI group was fed a diet containing 1.81 g/kg of ASI for 12 weeks; after the first 8 weeks, a calvarial critical-sized defect was created, and the rats were sacrificed 7, 14, and 28 days later. The calvarial bones of all the rats were then harvested for evaluation.
Results: Osteoblasts and osteoclasts were detected at higher levels in the ASI group compared with the control group at days 7, 14, and 28 of the calvarial defect (P<0.05). New bone formation was detected at higher levels in the ASI group compared with the controls at day 28 (P<0.05). However, new bone formation was not detected at days 7 and 14 in both the groups (P>0.05).
Conclusion: ASI supplementation significantly improved bone tissue healing in rats with critical-sized defects. This study demonstrated that ASI can enhance bone repair and has potential as a therapeutic regimen in humans.

• 出版日期2016