An antiproliferative xanthone of Symphonia pauciflora from the Madagascar rainforest

作者：Pan Ende; Cao Shugeng; Brodie Peggy J; Miller James S; Rakotodrajaona Rolland; Ratovoson Fidy; Birkinshaw Chris; Andriantsiferana Rabodo; Rasamison Vincent E; Kingston David G I^*

来源：Natural Product Communications, 2010, 5(5): 751-754.

• Clusiaceae
• Symphonia pauciflora
• xanthones
• Guttiferone
• antiproliferative activity

Investigation of a Malagasy endemic plant identified as Symphonia pauciflora Baker (Clusiaceae) for antiproliferative activities against the A2780 ovarian cancer cell line led to the isolation of a new compound identified as 2-(3,3-dimethylallyl)-7-methoxy-1,5,6-trihydroxy-2 '',2 ''-dimethylpyrano(6 '',5 '':3,4) xanthone (1) and the two known guttiferones A (2) and 1 (3). The structure elucidation of 1 was based on the analysis of its 1D and 2D NMR and mass spectral data. Compound 1 showed good antiproliferative activity with an IC(50) value of 3.8 mu M against the A2780 human ovarian cancer cell line, while the known guttiferone analogues (2 and 3) exhibited moderate activities with IC(50) values of 8.3 mu M and 7.8 mu M, respectively.

• 出版日期2010-5