Diastereoselective synthesis of alpha-(aminomethyl)-gamma-butyrolactones via a catalyst-free aminolactonization

作者:Ramachandran P Veeraraghavan*; Nicponski Daniel R
来源:Chemical communications, 2014, 50(96): 15216-15219.
DOI:10.1039/c4cc05765a

摘要

An auto-catalytic domino reaction, presumably involving an aza-Michael reaction, proton transfer, and lactonization, furnishing alpha-(aminomethyl)-gamma-butyrolactones in near quantitative yields and excellent diastereoselectivity is described.

  • 出版日期2014