A Non-Cross-Coupling Approach to Arene-Bridged Macrocycles: Synthesis, Structure, and Direct, Regioselective Functionalization of a Cycloparaphenylene Fragment

作者：Mitra Nirmal K; Meudom Rolande; Gorden John D; Merner Bradley L^*

来源：Organic Letters, 2015, 17(11): 2700-2703.

DOI：10.1021/acs.orglett.5b01102

A new synthetic strategy that employs a relatively unstrained, 1,4-diketo-bridged macrocycle as a precursor to a strained, 1,4-arene-bridged (bent para-phenylene) macrocycle has been developed. The distorted p-terphenyl nucleus (CPP fragment) of the macrocycle has been characterized by X-ray crystallography, and a direct, regioselective bromination protocol of the macrocyclic system is reported.

• 出版日期2015-6-5