MEDEX2015: Greater Sea-Level Fitness Is Associated with Lower Sense of Effort During Himalayan Trekking Without Worse Acute Mountain Sickness

作者：Rossetti Gabriella M K; Macdonald Jamie H; Smith Matthew; Jackson Anna R; Callender Nigel; Newcombe Hannah K; Storey Heather M; Willis Sebastian; van den Beukel Jojanneke; Woodward Jonathan; Pollard James; Wood Benjamin; Newton Victoria; Virian Jana; Haswell Owen; Oliver Samuel J^*

来源：High Altitude Medicine & Biology, 2017, 18(2): 152-162.

DOI：10.1089/ham.2016.0088

• acute mountain sickness
• arterial oxygen saturation
• exercise
• hypoxic ventilatory response
• maximal oxygen uptake

Rossetti, Gabriella M. K., Jamie H. Macdonald, Matthew Smith, Anna R. Jackson, Nigel Callender, Hannah K. Newcombe, Heather M. Storey, Sebastian Willis, Jojanneke van den Beukel, Jonathan Woodward, James Pollard, Benjamin Wood, VictoriaNewton, Jana Virian, OwenHaswell, and Samuel J. Oliver. MEDEX2015: Greater sea-level fitness is associated with lower sense of effort duringHimalayan trekking withoutworse acutemountain sickness. High Alt Med Biol. 18: 152-162, 2017.-This study examined the complex relationships of fitness and hypoxic sensitivity with submaximal exercise responses and acute mountain sickness (AMS) at altitude. Determining these relationships is necessary before fitness or hypoxic sensitivity tests can be recommended to appraise individuals' readiness for altitude. Forty-four trekkers (26 men; 18 women; 20-67 years) completed a loaded walking test and a fitness questionnaire in normoxia to measure and estimate sea-level maximal aerobic capacity (maximum oxygen consumption [V_ O2max]), respectively. Participants also completed a hypoxic exercise test to determine hypoxic sensitivity (cardiac, ventilatory, and arterial oxygen saturation responses to acute hypoxia, fraction of inspired oxygen [Fio2] = 0.112). One month later, all participants completed a 3-week trek to 5085m with the same ascent profile. On ascent to 5085m, ratings of perceived exertion (RPEascent), fatigue by BrunelMood Scale, and AMS were recorded daily. At 5085 m, RPE during a fixed workload step test (RPEfixed) and step rate during perceptually regulated exercise (STEPRPE35) were recorded. Greater sea-level V_ O2max was associated with, and predicted, lower sense of effort (RPEascent; r=-0.43; p < 0.001; RPEfixed; r=-0.69; p < 0.001) and higher step rate (STEPRPE35; r = 0.62; p < 0.01), but notworseAMS (r = 0.13; p = 0.4) or arterial oxygen desaturation (r = 0.07; p = 0.7). Lower RPEascent was also associated with better mood, including less fatigue (r = 0.57; p < 0.001). Hypoxic sensitivity was not associated with, and did not add to the prediction of submaximal exercise responses orAMS. In conclusion, participants with greater sea-level fitness reported less effort during simulated and actual trekking activities, had better mood (less fatigue), and chose a higher step rate during perceptually regulated exercise, but did not suffer fromworseAMSor arterial oxygen desaturation. Simple sea-level fitness testsmay be used to aid preparation for high-altitude travel.

• 出版日期2017-6