Antimicrobial activity of the constituents of Smallanthus sonchifolius leaves against methicillin-resistant Staphylococcus aureus

作者：Choi J G; Kang O H; Lee Y S; Oh Y C; Chae H S; Obiang Obounou B; Park S C; Shin D W; Hwang B Y; Kwon D Y^*

来源：European Review for Medical and Pharmacological Sciences, 2010, 14(12): 1005-1009.

• Antibacterial activity
• MRSA
• Smallanthus sonchifolius

Background and Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) has been a serious problem as its infection is associated with higher mortality and increase cost worldwide. In the present study, the antibacterial activity of enhydrin, polymatin B, allo-schkuhriolide from the leaves of Smallanthus sonchifolius was investigated.
Material and Methods: Enhydrin, polymatin B, allo-schkuhriolide from the leaves of Smallanthus sonchifolius were tested for antimicrobial activity using micro dilution broth method against 2 strains of ATCC 33591, ATCC 25923 and 15 strains of clinical isolates MRSA.
Results: The antibacterial activity of Smallanthus sonchifolius can safely be attributed to enhydrin as polymatin B, and allo-schkuhriolide are not showing any activity against Staphylococcus aureus strains. The enhydrin showed good antibacterial activity against all tested strains (MIC = 125-500 mu g/ml).
Discussion: These results suggest that only enhydrin can be considered as an antibacterial drug against MRSA.

• 出版日期2010-12