NUCLEOTIDE-SEQUENCE ANALYSIS OF VARIOLA VIRUS HINDIII-M-GENOME, L-GENOME, I-GENOME FRAGMENTS

作者：SHCHELKUNOV SN^*; BLINOV VM; TOTMENIN **; MARENNIKOVA SS; KOLYKHALOV AA; FROLOV IV; CHIZHIKOV VE; GYTOROV VV; GASHIKOV PV; BELANOV EF; BEL**IN PA; RESENCHUK SM; ANDZHAPARIDZE OG; SANDAKHCHIEV LS

来源：Virus Research, 1993, 27(1): 25-35.

DOI：10.1016/0168-1702(93)90110-9

• ORTHOPOXVIRUS
• VARIOLA VIRUS
• SEQUENCE ANALYSIS

DNA of the variola major virus strain India-1967 in the region of HindIII M, L, I fragments has been sequenced. Analysis of this sequence of 18029 bp revealed 19 potential open reading frames (ORFs). Four proposed proteins (L2R, H9R, L5L, L6R) contain metal-binding domains. Comparison of the variola virus (VAR) and vaccinia virus strain Copenhagen (COP) sequences show that the main differences are between proteins L1R and I5R. L1R contains 6 additional amino acid residues on the C-terminus. The protein I5R of VAR contains three Ca2+ binding domains but this COP has deletions in 2 of the 3 established domains. Possible functions of the predicted viral polypeptides are discussed.

• 出版日期1993-1