Murine models in blood transfusion: Allo-immunization, hemolysis

作者：Desmarets M^*; Noizat Pirenne F

来源：Transfusion Clinique et Biologique, 2011, 18(2): 115-123.

DOI：10.1016/j.tracli.2011.01.006

• Marine models
• Allo-immunization
• Transfusional reactions
• Immunehematology

Mice represent an animal model that can be easily manipulated. Mice have been used to model many human diseases. This review addresses murine models of immunity directed against red blood cell antigens as well as models of antibody and non-antibody mediated hemolysis. These models allow for a better understanding of the side effects of transfusion, such as red blood cell allo-immunization and post-transfusional hemolytic reactions. They also help explore strategies to treat and prevent these side effects in ways that would not be available using clinical research alone.

• 出版日期2011-4