Multi-Channel SQUID-Based Ultra-High-Sensitivity In-Vitro Detections for Bio-Markers of Alzheimer's Disease Via Immunomagnetic Reduction

作者：Chiu M J^*; Horng H E; Chieh J J; Liao S H; Chen C H; Shih B Y; Yang C C; Lee C L; Chen T F; Yang S Y; Hong C Y; Yang H C

来源：IEEE Transactions on Applied Superconductivity, 2011, 21(3): 477-480.

DOI：10.1109/TASC.2010.2087304

• Alzheimer's disease
• immunoassay
• magnetic nanoparticles
• SQUIDs

Via immunomagnetic reduction assay, bio-molecules can be quantitatively detected with the aid of bio-functionalized magnetic nanoparticles, which are used as labeling markers for specific bio-molecules. To achieve an ultra-high sensitivity in the detection of bio-molecules, the superconducting quantum interference device (SQUID) looks very promising as a sensor for the magnetic signal that are related to the concentration of the detected bio-molecules. We had developed a single channel SQUID-based magnetosusceptometer, but for increasing the detection through-put, we have developed a multi-channel SQUID-based magnetosusceptometer. In this work, the design and the working principle of a 4-channel SQUID-based magnetosusceptometer are introduced. By utilizing scanning technology, 4 samples can be logged into a SQUID-based magnetosusceptometer simultaneously. Be noted that only one single SQUID magnetometer has been used in the magnetosusceptometer. The precision and the sensitivity of detecting bio-molecules by using a 4-channel SQUID-based magnetosusceptometer have been investigated. The detected bio-molecules are biomarkers for Alzheimer's disease.

• 出版日期2011-6
• 单位河北医科大学