Antiglucocorticoids, Neurogenesis and Depression

作者：Fitzsimons Carlos P; van Hooijdonk Lenneke W A; Morrow John A; Peeters Bernard W M M; Hamilton Niall; Craighead Mark; Vreugdenhil Erno^*

来源：Mini Reviews in Medicinal Chemistry, 2009, 9(2): 249-264.

DOI：10.2174/138955709787316001

• Stress
• glucocorticoid receptor
• dentate gyrus
• hippocampus
• neurogenesis
• antidepressants
• depression
• double-cortin-like kinase
• anti-glucocorticoids

Recent evidence suggests that antiglucocorticoids, like conventional antidepressants, may recover depressive symptoms by boosting hippocampal neurogenesis. Here, we explore several possible antiglucocorticoid-based antidepressive therapeutic strategies. Firstly, we review specific glucocorticoid receptor/antagonist interactions. Secondly, we discuss a potential new therapeutic target, doublecortin-like kinase, which regulates glucocorticoid signaling in neuronal progenitor cells.

• 出版日期2009-2