Adipokines and ghrelin in gastric cancer cachexia

作者：Kerem Mustafa^*; Ferahkose Zafer; Yilman Utku Tonguc; Pasaoglu Hatice; Ofluoglu Ebru; Bedirli Abdulkadir; Salman Bulent; Sahin Tevfik Tolga; Akin Murat

来源：World Journal of Gastroenterology, 2008, 14(23): 3633-3641.

DOI：10.3748/wjg.14.3633

• gastric cancer
• cachexia
• resistin
• ghrelin
• leptin
• adiponectin
• insuline

AIM: To investigate the roles of the adipocytokines, ghrelin and leptin in gastric cancer cachexia.
METHODS: Resistin, ghrelin, leptin, adiponectin, insulin and insulin-like growth factor (IGF-I), were measured in 30 healthy subjects, and 60 gastric cancer patients of which 30 suffered from cancer-induced cachexia and 30 served as a control group. The relationships between hormones, body mass index (BMI) loss ratio, age, gender, and Glasgow Prognostic Score (GPS) were investigated.
RESULTS: Cachexia patients had higher tumor stage and GPS when compared with non-cachexia patients (P < 0.05). Ghrelin, resistin, leptin, adiponectin and IGF-I, showed a significant correlation with BMI loss ratio and GPS (P < 0.05). A strong correlation was seen between GPS and BMI loss (R = -0.570, P < 0.0001). Multivariate analysis indicated that BMI loss was significantly independent as a predictor of ghrelin, resistin, leptin and IGF-I (P < 0.05). Existence of an important significant relationship between resistin and insulin resistance was also noted.
CONCLUSION: These results showed that serum ghrelin, leptin, adiponectin, and IGF-I play important roles in cachexia-related gastric cancers. No relationship was found between resistin and cancer cachexia. Also, because of the correlation between these parameters and GPS, these parameters might be used as a predictor factor.

• 出版日期2008-6-21