Detection prevalence of inducible clindamycin resistance in Coagulase-Negative Staphylococci (CoNS) isolates in an Iranian 1000-bed tertiary Care Hospital Using D Test

作者：Rahbar Mohammad; Mohammad Zadeh Mona; Asl Hossein Masoumi; Azimi Leila; Lari Abdolaziz Rastegar^*

来源：Healthmed, 2012, 6(8): 2642-2646.

• clindamycin
• inducible resistance
• Coagulase-Negative Staphylococci

Background and objectives: Clindamycin is an antibiotic which usually can be used for treatment of infection of skin and soft tissue infection caused by staphylococci. The aim of this study was to determine prevalence of inducible clindamycin resistance among coagulase-negative staphylococci that were isolated in Iranian 1000-bed tertiary care hospital. %26lt;br%26gt;Methods: A total of 114 strains of coagulase-negative staphylococci were isolated from clinical specimens. All isolates were identified by conventional microbiological methods. Inducible clindamycin resistance was performed by double disk diffusion method as recommended by Clinical Laboratory Standards Institute (CLSI). %26lt;br%26gt;Results: Of 114 isolates coaagulase-negative staphylococci, 107(93.8%) strains were isolated from blood cultures. Of the 114 CoNS isolates 61(53.50%) were resistant to both erythromycin and clindamycin. 10 (8.77%) isolates were resistant to erythromycin but susceptible to clindamycin. Of 114 CoNS 32 (28.07%) isolates were susceptible to both erythromycin and clindamycin. The rate of inducible clindamycin resistance was 9.64%. All inducible clindamycin were methicillin resistant. %26lt;br%26gt;Conclusion: Resistance to antimicrobial agents such as macrolides might not be readily apparent by routine testing. It is recommended to implement of the D-test or the Disk induction test as a simple, practical method with routine antibiotic susceptibility testing, for detection inducible and constitutive clindamycin resistance among staphylococci isolates.

• 出版日期2012