Parecoxib reduces renal injury in an ischemia/reperfusion model in rats

作者：Calistro Neto Jose Pedro; Torres Romulo da Costa; Goncalves Giovanna Maria; da Silva Leopoldo Muniz; Custodio Domingues Maria Aparecida; Pinheiro Modolo Norma Sueli; Moreira de Barros Guilherme Antonio

来源：Acta Cirurgica Brasileira, 2015, 30(4): 270-275.

DOI：10.1590/S0102-865020150040000006

• Parecoxib
• Ischemia
• Reperfusion
• Kidney
• Rats

PURPOSE: To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.
METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.
RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.
CONCLUSION: Parecoxib resulted in renal protection in this experimental model.

• 出版日期2015-4