Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting

作者：Hatting Maximilian; Rines Amy K; Luo Chi; Tabata Mitsuhisa; Sharabi Kfir; Hall Jessica A; Verdeguer Francisco; Trautwein Christian; Puigserver Pere

来源：Cell Metabolism, 2017, 25(2): 428-437.

DOI：10.1016/j.cmet.2016.12.007

• CLK2
• Intermittent fasting
• Brown fat
• High-fat diet
• Diet-induced thermogenesis
• Refeeding
• UCP1
• P-CREB
• PP2A

Summary(#br)A promising approach to treating obesity is to increase diet-induced thermogenesis in brown adipose tissue (BAT), but the regulation of this process remains unclear. Here we find that CDC-like kinase 2 (CLK2) is expressed in BAT and upregulated upon refeeding. Mice lacking CLK2 in adipos...

• 出版日期2017-2-7