Aortic root disease in tetralogy of Fallot

作者：Tan Ju L; Gatzoulis Michael A; Ho Siew Y^*

来源：Current Opinion in Cardiology, 2006, 21(6): 569-572.

DOI：10.1097/01.hco.0000245732.09594.2f

• aorta
• congenital heart disease
• tetralogy of Fallot

Purpose of review Progressive aortic root dilation is a recognized feature of tetralogy of Fallot even in patients following initial reparative surgery. The underlying pathophysiology was initially attributed to altered hemodynamics resulting from longstanding volume overloading and stretching of the aortic root from increased right to left shunting. This review explores the pathophysiology and possible mechanisms for the aortic dilation, and whether these changes are a reflection of the initial hemodynamic stress or a cellular expression of an unrecognised gene associated with conotruncal defects.
Recent findings The recent publication of two case reports of aortic aneurysm and dissection in tetralogy of Fallot patients resized emphasized the fact that aortic root dilatation tan no longer be regarded as a benign, problem in tetralogy of Fallot patients. Findings of intrinsic histological abnormalities in the aortic root and ascending aorta of tetralogy of Fallot patients suggest that intrinsic abnormalities may also play an important causative role.
Summary A better understanding of the pathophysiology will help to formulate future treatment and management strategies in the subgroup of tetralogy of Fallot patients with progressive aortic dilatation.

• 出版日期2006-11