A PPAR delta-selective antagonist ameliorates IMQ-induced psoriasis-like inflammation in mice

作者：Wang, Xuguo; Hao, Yangyang; Wang, Xiaohuan; Wang, Lumei; Chen, Yongchun; Sun, Jun^*; Hu, Jinhong^*

来源：International Immunopharmacology, 2016, 40: 73-78.

DOI：10.1016/j.intimp.2016.08.027

• Psoriasis
• PPAR delta
• Selective antagonist
• Pathogenesis

PPAR delta is highly expressed in skin, especially keratinocytes, and its expression is increased in psoriatic lesions. However, the potential role of PPAR delta in the pathogenesis of psoriasis remains undefined. Mice treated with Imiquimod (IMQ) to induce psoriasis can be used to evaluate the pathogenesis of psoriasis, and this model has become one of the most important in vivo research tools for research on the disease. In the current study, we showed that PPAR delta was highly expressed in the skin of IMQ-induced psoriasis mice. To further understand the impact of PPAR delta in psoriasis, we used these mice in a series of experiments to evaluate the pathogenesis of psoriasis. We found that PPAR delta was highly expressed in both psoriatic lesions and normal skin in IMQ-induced psoriasis mice. Furthermore, the expression of PPAR delta-relevant lipases was also significantly increased. The PPAR delta-selective antagonist GSK3787 ameliorated the observed inflammation in the skin of the experimental mice. Based on these results, PPAR delta may be a potential target for the effective treatment of psoriasis.

• 出版日期2016-11
• 单位复旦大学; 中国人民解放军第二军医大学; 安徽医科大学