A highly enantioselective catalyst for asymmetric hydroformylation of [2.2.1]-bicyclic olefins

作者：Huang JK^*; Bunel E; Allgeier A; Tedrow J; Storz T; Preston J; Correll T; Manley D; Soukup T; Jensen R; Syed R; Moniz G; Larsen R; Martinelli M; Relder PJ

来源：Tetrahedron Letters, 2005, 46(45): 7831-7834.

DOI：10.1016/j.tetlet.2005.09.012

• asymmetric hydroformylation
• TangPhos
• [2.2.1]-bicyclic olefin

Rh(CO)(2)(acac)/TangPhos was found to be a highly enantio selective catalyst for asymmetric hydroformylation of norbornylene under mild conditions. Application of the protocol to the desymmetrization of other [2.2.1]-bicyclic olefins gave moderate to excellent enantioselectivity (55-92% ee).

• 出版日期2005-11-7