An immunohistochemical evaluation of BMP-2,-4, osteopontin, osteocalcin and PCNA between ossifying fibromas of the jaws and peripheral cemento-ossifying fibromas on the gingiva

作者：Ono Akiko; Tsukamoto Goichi^*; Nagatsuka Hitoshi; Yoshihama Yasuto; Rivera Rosario Santos; Katsurano Miki; Yao Mayumi; Sasaki Akira

来源：Oral Oncology, 2007, 43(4): 339-344.

DOI：10.1016/j.oraloncology.2006.03.017

• bone morphogenetic protein
• osteopontin
• osteocalcin
• proliferating cell nuclear antigen
• oxytalan fiber
• ossifying fibroma
• peripheral cemento-ossifying fibroma

The present study examined histological difference between ossifying fibromas (OF, n = 5) and peripheral cemento-ossifying fibromas (PCOF, n = 7). Bone morphogenetic proteins (BMP)-2 and -4, osteopontin (OPN), osteocalcin (OCN) and proliferating cell nuclear antigen (PCNA) were used for the immunohistochemical examinations. Oxytatan fibers present at the periodontal tissue were stained to determine the tumor cell origin. Many OFs showed high immunohistochemical reactions for BMP-2, -4 and OPN compared to those of PCOFs. PCNA index (IP) of OFs was significantly higher than that of PCOFs. All the PCOFs showed a high expression of oxytalan fibers. Only two OFs exhibited a small number of oxytalan fibers. These results suggest that PCOF has only little ability to form hard tissue and seems to be a reactive lesion. The expression of oxytalan fibers reveals that OF does not only originate from periodontat tissue.

• 出版日期2007-4