科研之友
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摘要
Until now it has been assumed, that methyl-phenidate (MPH) exerts its action preferably on dopamine metabolism; a blockade of striatal dopamine transporter by MPH with the consequence of an elevation of dopamine in the synaptic cleft has been described. Meanwhile results have been presented, whereupon MPH also blocks the norepinephrine transporter, thus influencing dopamine and norepinephrine metabolism especially in frontal regions. Further investigations showed an influence of MPH also on acetylcholine and histamine. In contrast to amphetamine, methamphetamine, cocaine and MDMA (Ecstasy), MPH seems not to effect the serotonine transporter in a remarkable extent.
- 出版日期2010
