Anti-Hu Antibody-associated Paraneoplastic Neurological Syndrome Showing Peripheral Neuropathy and Atypical Multifocal Brain Lesions

作者：Shibata Makoto; Uchida Megumi; Tsukagoshi Setsuki; Yamaguchi Koichi; Yamaguchi Aya; Furuta Natsumi; Makioka Kouki; Maeno Toshitaka; Fujita Yukio; Kurabayashi Masahiko; Ikeda Yoshio^*

来源：Internal Medicine, 2015, 54(23): 3057-3060.

DOI：10.2169/internalmedicine.54.4867

• paraneoplastic neurological syndrome (PNS)
• anti-Hu antibody
• small-cell lung cancer (SCLC)
• peripheral neuropathy
• cauda equina enhancement
• encephalopathy

A 64-year-old Japanese woman presented with a three-month history of progressive numbness and weakness of the lower extremities. A neurological examination and nerve conduction study indicated sensorimotor polyneuropathy. Since the serum anti-Hu antibody titer was remarkably elevated, paraneoplastic neurological syndrome was highly suspected. A thoracoscopic biopsy of the hilar lymph nodes, in which F-18-fluorodeoxyglucose uptake was obviously increased, revealed pathological findings for small-cell lung cancer (SCLC). Subsequently, the patient presented with generalized tonic-clonic seizures, and cerebral MRI showed reversible multifocal brain lesions, considered to reflect paraneoplastic encephalopathy. After two courses of chemotherapy for SCLC, the brain lesions totally disappeared.

• 出版日期2015