Direct Assembly of 2-Oxazolidinones by Chemical Fixation of Carbon Dioxide

作者：Niemi Teemu; Perea Buceta Jesus E; Fernandez Israel; Alakurtti Sami; Rantala Erika; Repo Timo^*

来源：Chemistry - A European Journal, 2014, 20(29): 8867-8871.

DOI：10.1002/chem.201402368

• 2-oxazolidones
• antibiotics
• carbon dioxide activation
• carbon dioxide fixation
• density functional calculations

The reaction of beta- and gamma-haloamines with carbon dioxide to give pharmaceutically relevant 2-oxazolidinones and 1,3-dioxazin-2-ones, was found to proceed efficiently in the presence of a base and in the absence of catalyst. After optimization of reaction conditions, the system was successfully expanded to a variety of haloamines, even at multigram scale. The reaction was further studied in silico by DFT calculations.

• 出版日期2014-7-14