An efficient one-pot four-step domino reaction for the synthesis of C2-substituted 3-methylcyclohex-2-enones

作者：Goncalves Sylvie; Maillos Philippe; Nicolas Marc; Wagner Alain; Baati Rachid^*

来源：Tetrahedron, 2010, 66(39): 7856-7860.

DOI：10.1016/j.tet.2010.07.029

• Domino reaction
• Enone
• Cyclization
• beta-Ketoester

An efficient one-pot four-step domino reaction of substituted beta-ketoesters has been optimized giving rise to a large panel of C2-substituted 3-methylcyclohex-2-enones, an important scaffold for the preparation of various initiators for cationic or radical cyclizations. The developed methodology is quite general and applicable to a wide range of beta-ketoester substrates, allowing the introduction of various functionalities at the C2 position of the 3-methylcyclohex-2-enones, in good to excellent yields.

• 出版日期2010-9-25