Association of serum 25-hydroxyvitamin D with insulin resistance and beta-cell function in a healthy Chinese female population

作者：Tao, Min-fang; Zhang, Zeng; Ke, Yao-hua; He, Jin-wei; Fu, Wen-zhen; Zhang, Chang-qing; Zhang, Zhen-lin^*

来源：Acta Pharmacologica Sinica, 2013, 34(8): 1070-1074.

DOI：10.1038/aps.2013.13

• vitamin D
• 25-hydroxyvitamin D
• type 2 diabetes
• beta-cell function
• insulin resistance
• female

Aim: To assess associations of the serum level of 25-hydroxyvitamin D with insulin resistance and beta-cell function in a healthy Chinese female population.
Methods: This cross-sectional study included 1382 female participants free of type 2 diabetes who were recruited in Shanghai. Blood samples were collected within a winter season and the serum levels of 25-hydroxyvitamin D, fasting plasma glucose and insulin, and other biochemical parameters were determined. Insulin resistance and beta-cell function were assessed using the homeostasis model assessments of insulin resistance (HOMA-IR) and beta-cell HOMA-B), respectively.
Results: Multiple linear regression analyses adjusted for age, parathyroid hormone, Ca2+ and BMI revealed that independent inverse associations existed between the serum level of 25-hydroxyvitamin D and HOMA-IR (P<0.001) and between the serum level of 25-hydroxyvitamin D and HOMA-B (P=0.001).
Conclusion: Serum vitamin D level is significantly and independently associated with insulin resistance and beta-cell function in a healthy Chinese female population.

• 出版日期2013-8
• 单位上海交通大学