Angiogenesis-Related Factors are Molecular Targets for Diagnosis and Treatment of Patients with Esophageal Carcinoma

作者：Oshima Yoko; Yajima Satoshi; Yamazaki Kunihiro; Matsushita Kazuyuki; Tagawa Masatoshi; Shimada Hideaki^*

来源：Annals of Thoracic and Cardiovascular Surgery, 2010, 16(6): 389-393.

Angiogenesis plays an essential role in the growth and metastasis of esophageal carcinoma. Vascular endothelial growth factor, thymidine phosphorylase, fibroblast growth factor, midkine, and hepatocyte growth factor have been reported to be vital molecules for tumor angiogenesis. Polymorphisms in gene encoding angiogenic factors or their receptors may alter protein expression and/or activity. Increased angiogenic-factor expression and increased serum levels of these molecules were found to be associated with poor treatment response and poor prognosis. We reviewed the clinicopathological significance of angiogenesis-related molecules in patients with esophageal carcinoma. Antiangiogenic molecular-treatment strategies are also discussed. (Ann Thorac Cardiovasc Surg 2010; 16: 389-393)

• 出版日期2010-12