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An Official American Thoracic Society/European Respiratory Society Statement: Research Questions in Chronic Obstructive Pulmonary Disease
Celli Bartolome R
Decramer Marc
Wedzicha Jadwiga A
Wilson Kevin C
Agusti Alvar
Griner Gerard J
MacNee William
Make Barry J
Rennard Stephen I
Stockley Robert A
Vogelmeier Claus
Anzueto Antonio
Au David H
Barnes Peter J
Burgel Pierre Regis
Calverley Peter M
Casanova Ciro
Clini Enrico M
Cooper Christopher B
Coxson Harvey O
Dusser Daniel J
Fabbri Leonardo M
Fahy Bonnie
Ferguson Gary T
Fisher Andrew
Fletcher Monica J
Hayot Maurice
American Journal of Respiratory and Critical Care Medicine, 191(7), pp 831-844, 2015-4-1
Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this Official American Thoracic Society (ATS)/European Respiratory Society (ERS) Research Statement is to describe evidence related to diagnosis, assessment, and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management. Methods: Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarized, and then salient knowledge gaps were identified. Results: Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus. Conclusions: Great strides have been made in the diagnosis, assessment, and management of COPD as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ERS Research Statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centered Outcomes.
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