Ameliorative Effects of Monascus pilosus-Fermented Black Soybean (Glycine max L. Merrill) on High-Fat Diet-Induced Obesity

作者：Oh Hong Geun; Kang Young Rye; Lee Hak Yong; Kim Jung Hoon; Shin Eun Hye; Lee Bong Gun; Park Sang Hoon; Moon Dae In; Kim Ok Jin; Lee In Ae; Choi Jongkeun; Lee Ji Ean; Park Kwang Hyun; Suh Joo Won^*

来源：Journal of Medicinal Food, 2014, 17(9): 972-978.

DOI：10.1089/jmf.2012.2740

• anti-obesity effect
• fermented black soybean
• high-fat diet-induced obesity
• hyperglycemia
• Glycine max L. Merrill
• Monascus pilosus

The purpose of this study was to examine the antiobesity effects of Monascus pilosus-fermented black soybean (F-BS) in C57BL/6 mice with high-fat diet (HFD)-induced obesity. F-BS (oral, 0.5 and 1.0 g/kg per body weight, twice per day) ameliorated obesity by reducing body and liver weight increases, and regulating blood glucose and cholesterol levels in C57BL/6 mice fed a control or HFD with oral administration of F-BS for 12 weeks. F-BS suppressed the growth of epididymal, retroperitoneal, and perirenal fat pads by preventing increases in the adipocyte size. Moreover, the levels of blood glucose, total cholesterol, and leptin were significantly lowered by F-BS administration in a dose-dependent manner. These results indicated that F-BS is a beneficial food supplement for preventing obesity, controlling blood glucose, and lowering cholesterol. Future research strategies should address the mechanisms that selectively regulate obesity, including hyperglycemia and hypercholesterolemia.

• 出版日期2014-9