Protein Binding in Patients With Late-Life Depression

作者：Kumar Anand^*; Kepe Vladimir; Barrio Jorge R; Siddarth Prabha; Manoukian Vicki; Elderkin Thompson Virginia; Small Gary W

来源：Archives of General Psychiatry, 2011, 68(11): 1143-1150.

DOI：10.1001/archgenpsychiatry.2011.122

Context: Depression has been identified as a risk factor and a prodrome of dementia. Common neurobiological mechanisms may underlie this clinical and phenomenologic overlap.
Objective: To examine and compare protein (amyloid and tau) binding in critical brain regions in patients diagnosed as having late-life major depressive disorder (MDD) and healthy control individuals using 2-(1-{6-[(2-[(18)F]fluoroethyl)(methyl)-amino]-2-naphthyl}ethylidene) malononitrile ([(18)F] FDDNP) positron emission tomography.
Design: A cross-section neuroimaging study using positron emission tomography.
Setting: University of California, Los Angeles.
Patients: Our samples comprised 20 patients diagnosed as having MDD and 19 healthy control individuals of comparable age, sex, and educational level.
Main Outcome Measure: Relative distribution volume in regions of interest was used as the measure of [(18)F]FDDNP binding in all study participants.
Results: When compared with controls, [(18)F] FDDNP binding was significantly higher overall and in the posterior cingulate and lateral temporal regions in the MDD group.
Conclusions: These findings suggest that neuronal injury associated with higher protein load in critical brain regions might provide a mechanism in the pathophysiologic manifestation of MDD in late life and have implications for the therapeutics of depression in elderly individuals.

• 出版日期2011-11