Apolipoprotein E Gene Polymorphism and the Risk of Intracerebral Hemorrhage in the Chinese Population

作者：Zhang Rongjun; Wang Xiaofeng^*; Liu Jianxin; Yang Shuzhen; Tang Zongchun; Li Shuande; Peng Yabin; Zhang Hongbin; Yang Xingkui; Zhou Yongchun; Shao Wei

来源：Genetic Testing and Molecular Biomarkers, 2012, 16(1): 63-66.

DOI：10.1089/gtmb.2011.0103

Prior studies investigating the association between apolipoprotein E (APOE) gene polymorphism and the risk of intracerebral hemorrhage (ICH) have been inconsistent and limited to small sample sizes. The aim of this study was to test the hypothesis that APOE gene polymorphisms are associated with the risk of ICH in Chinese Han patients. We enrolled 180 ICH patients and 180 controls. APOE genotype was determined by using a polymerase chain reaction-restriction fragment length polymorphism assay. ICH patients had a significantly lower frequency epsilon 3/epsilon 3 [odds ratio (OR) = 0.45, 95% confidence interval (CI) = 0.28, 0.71; p = 0.001] and 63 allele (OR = 0.51, 95% CI = 0.35, 0.76; p = 0.001) than healthy controls. ICH patients also had a significantly higher frequency epsilon 3/epsilon 4 (OR = 3.61, 95% CI = 1.89, 6.88; p < 0.001) and epsilon 4 allele (OR = 3.00, 95% CI = 1.76, 5.13; p < 0.001) than healthy controls. This study suggests that the APOE genotype is associated with the risk of ICH in Chinese Han patients.

• 出版日期2012-1