Antioxidant and vasorelaxant activities of the Turraeanthus africanus methanol extract

作者：Dongmo Alain Bertand^*; Dzikouk Guillaume Dzissin; Massoma Dieudonne Lembe; Nguelefak Telesphore Benoit; Vardamides Catherine Juliette; Kamanyi Albert; Vierling Wolfgang

来源：Pharmaceutical Biology, 2009, 47(12): 1123-1129.

DOI：10.3109/13880200903008674

• Antioxidant activity
• Turraeanthus africanus
• vasorelaxant activity

The present studies evaluate the antioxidant and vasorelaxant activities of the methanol stem bark extract of Turraeanthus africanus (Welw.) Pellegr. (Meliaceae). The antioxidant property investigated through the DPPH scavenging activity showed that the methanol extract from the stem bark of T africanus was active with an inhibition rate of 72.47% at 500 mu g/mL and IC(50) of 29.2 mu g/mL. This extract (0.1-700 mu g/mL) induced a concentration-dependent relaxation of guinea-pig aortic rings precontracted with noradrenaline or KCl, with a maximum relaxation reaching 87.55 and 97.42%, respectively, at a concentration of 700 mu g/mL. The extract showed no significant effect on the electrically induced contraction of the guinea-pig papillary muscle. The results of this study indicate that the extract from the stem bark has interesting antioxidant and vasorelaxant properties and represents a potential source of medicine for the treatment of cardiovascular diseases.

• 出版日期2009-12