A fractional-order delay differential model for Ebola infection and CD8(+) T-cells response: Stability analysis and Hopf bifurcation

作者：Latha V Preethi; Rihan Fathalla A^*; Rakkiyappan R; Velmurugan G

来源：International Journal of Biomathematics, 2017, 10(8): 1750111.

DOI：10.1142/S179352451750111X

• Ebola virus
• CTL response
• Hopf bifurcation
• stability
• time-delay

In this paper, we study a fractional-order model with time-delay to describe the dynamics of Ebola, virus infection with cytotoxic T-lymphocyte (CTL) response in vivo. The time-delay is introduced in the CTL response term to represent time required to stimulate the immune system. Based on fractional Laplace transform, some conditions on stability and Hopf bifurcation are derived for the model. The analysis shows that, the fractional-order with time-delay can effectively enrich the dynamics and strengthen the stability condition of fractional-order infection model. Finally, the derived theoretical results are justified by some numerical simulations.

• 出版日期2017-11