Anti-angiogenesis in neuroblastoma

作者:Ribatti Domenico*
来源:Critical Reviews in Oncology/Hematology, 2013, 86(3): 212-221.
DOI:10.1016/j.critrevonc.2012.11.004

摘要

The nature of the angiogenic balance in neuroblastoma is complex, and a spectrum of angiogenesis stimulators and inhibitors have been detected in neuroblastoma tumours. The complex relationships between angiogenic cascade and anti-angiogenic agents in the tumour vascular phase have indicated that anti-angiogenesis can be considered as a strategy for the adjuvant therapy of neuroblastoma. The major goal is to establish if inhibition of angiogenesis is a realistic therapeutic strategy for inhibiting tumour cell dissemination and the formation of metastasis in neuroblastoma.

  • 出版日期2013-6