Association between T102C 5-HT2A receptor gene polymorphism and 5-year mortality risk among Brazilian Amazon riparian elderly population

作者：Silva Talis O; Jung Ivo; Trott Alexis^*; Bica Claudia G; Casarin Jeferson N; Fortuna Paola C; Ribeiro Euler E; de Assis Fernanda D; Figueira Guilherme C; Barbisan Fernanda; Manica Cattani Maria Fernanda; Bonadiman Beatriz S R; Houenou Lucien J; do Prado Lima Pedro Antonio S; da Cruz Ivana B M

来源：American Journal of Human Biology, 2017, 29(5): e23016.

DOI：10.1002/ajhb.23016

ObjectiveSerotonin (5-HT) is a pleiotropic molecule that exerts several functions on brain and peripheral tissues via different receptors. The gene for the 5-HT2A receptor shows some variations, including a T102C polymorphism, that have been associated with increased risk of neuropsychiatric and vascular disorders. However, the potential impact of 5-HT2A imbalance caused by genetic variations on the human lifespan has not yet been established.
METHODSWe performed a prospective study involving an Amazon riparian elderly free-living population in Maues City, Brazil, with a 5-year follow-up. Out of a cohort of 637 subjects selected in July, 2009, we genotyped 471 individuals, including 209 males (44.4%) and 262 females (55.6%), all averaging 72.37.8 years of age (ranging from 60 to 100 years).
RESULTSThe T102C-SNP genotypic frequencies were 14.0% TT, 28.0% CC, and 58.0% CT. From 80 elderly individuals who died during the period investigated, we observed significantly (P=.005) higher numbers of TT carriers (27.3%) and CC carriers (21.2%), compared to heterozygous CT carriers (12.5%). Cox-regression analysis showed that association between the T102C-SNP and elderly survival was independent of age, sex, and other health variables.
CONCLUSIONSOur findings strongly suggest that imbalance in 5-HT2A may cause significant disturbances that lead to an increased susceptibility to death for individuals who are over 60 years of age.

• 出版日期2017-10