Direct electron transfer of hemoglobin in a biocompatible electrochemical system based on zirconium dioxide nanotubes and ionic liquid

作者：Ma, Yanhui; Zhan, Guoqing; Ma, Ming; Wang, Xian; Li, Chunya^*

来源：Bioelectrochemistry, 2012, 84: 6-10.

DOI：10.1016/j.bioelechem.2011.09.003

• ZrO2
• Nanotubes
• Ionic liquid
• Hemoglobin
• Direct electrochemistry

Highly-ordered zirconium dioxide (ZrO2) nanotubes were prepared with porous anodic alumina as the template by the liquid phase deposition technique. The obtained ZrO2 nanotubes were characterized by transmission electron micrograph (TEM) and X-ray diffraction (XRD). A new biocompatible nano-platform for the immobilization of hemoglobin (Hb) was developed by coating a chitosan (CHI) solution, in which the ZrO2 nanotubes, 1-butyl-3-methylimidazolium tetrafluoroborate ionic liquid ([BMIM]BF4) and Fib were dispersed, onto a glassy carbon electrode surface. Direct electrochemistry of the immobilized Hb on the electrode surface was then investigated. The results indicated that remarkable improvements on the direct electrochemistry of Hb were achieved. In addition, the potential application of the Hb immobilized electrode (Hb/ZrO2/[BMIM]BF4/CHI/GCE) in biosensing was demonstrated by the catalytic electrochemical reduction of nitrite ion (NO2-) in an aqueous solution.

• 出版日期2012-4
• 单位中南民族大学