Post-traumatic Fungal Keratitis Caused by Carpoligna sp.

作者：Chew Hall F^*; Jungkind Donald L; Mah Dean Y; Raber Irving M; Toll Adam D; Tokarczyk Mindy J; Cohen Elisabeth J

来源：Cornea, 2010, 29(4): 449-452.

DOI：10.1097/ICO.0b013e3181af3954

• Carpoligna
• fungal keratitis
• trauma
• natamycin
• voriconazole
• amphotericin B

Purpose: To report the first case of fungal keratitis caused by presumed Carpoligna species.
Methods: A 37-year-old gardener sustained a full-thickness, stellate corneal laceration while cutting wood outdoors with a circular saw. Two months after surgical repair, he developed a severe infectious keratitis with descemetocoele at the apex of the original stellate laceration.
Results: Culture results confirmed fungal elements without evidence of bacteria. Oral and topical voriconazole were initiated. Due to compliance and cost issues, voriconazole was replaced with natamycin 5% prior to discharge from hospital. The patient improved and healed without perforation. The patient was left with a central stromal scar. DNA extraction from the fungal colony allowed PCR amplification of the 28s ribosomal RNA region of the fungus that led to the diagnosis of Carpoligna pleurothecii. Corticosteroids were never used during the patient's treatment.
Conclusion: This is the first reported case of infectious keratitis caused by presumed Carpoligna species. The treatment for Carpoligna pleurothecii keratitis includes voriconazole, natamycin, and possibly amphotericin B.

• 出版日期2010-4