摘要

The asymmetric alkylation of a tert-butyl benzophenone Schiff base derivative in water has been successfully carried out in a ';reversed-phase reaction';. The effects of chiral phase-transfer catalysts (PTCs), electrophiles, and reaction conditions (temperature, concentration, and the ratio of reagents, etc.) were investigated. Under the optimized conditions high chemical yield (99%) and good ee (up to 87%) were obtained.