Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections

作者：Roberts Craig W; Henriquez Fiona L^*

来源：Experimental Parasitology, 2010, 126(1): 91-96.

DOI：10.1016/j.exppara.2009.11.016

• Acanthamoeba
• Drug targets
• Drug validation

New more efficacious antimicrobials as required for the treatment of Acanthamoeba infections as those currently available require arduous treatment regimes, are not always effective and are poorly active against the cystic stages. Herein, we review potential drug targets including tubulin, alternative oxidase, amino acid biosynthesis and myosin. In addition, we review the literature for current missing tools and resources for the identification, validation and development of new antimicrobials for this organism. Additional targets should come to light through a concerted genome sequencing effort.

• 出版日期2010-9