A highly efficient [3+2] cycloaddition of nitrile oxides and azomethine imines to N-vinylpyrroles

作者：Efremova Mariia M; Molchanov Alexander P^*; Stepakov Alexander V; Kostikov Rafael R; Shcherbakova Victoriya S; Ivanov Andrey V

来源：Tetrahedron, 2015, 71(14): 2071-2078.

DOI：10.1016/j.tet.2015.02.058

• Pyrroles
• Cycloaddition
• Nitrile oxides
• Azomethine imines
• Stereoselectivity

1,3-Dipolar cycloaddition of various nitrile oxides to substituted N-vinylpyrroles proceed with high efficiency and selectivity with the formation of single isomer of 5-pyrrolyl-substituted isoxazoline. The reaction of N-vinylpyrroles with cyclic azomethine imines occurs regioselectively affording 7-(pyrrol-1-yl)- substituted pyrazolo[1,2-a]pyrazolones as a mixture of two diastereomers.

• 出版日期2015-4-8