Aervfuranoside: A New Chlorinated Dibenzofuran Glycoside and other Metabolites from the Flowers of Aerva javanica

作者：Musaddiq Sara; Saeed Muhammad Saqib; Riaz Naheed; Nazir Mamona; Khatoon Tasneem; Jabbar Abdul; Ismail Tayaba; Ashraf Muhammad; Khakwani Samia; Ashraf Abida; Saleem Muhammad^*

来源：Journal of the Chemical Society of Pakistan, 2017, 39(4): 572-577.

• Aerva javanica
• Secondary Metabolites
• Characterization
• Enzyme Inhibition

Aervfuranoside (1), a new chlorinated dibenzofuran glycoside together with ten (2-11) known compounds were isolated from ethyl acetate soluble fraction of methanolic extract of the flowers of Aerva javanica. The structures of isolates were elucidated by the combination of 1D (H-1 and C-13-NMR), 2D (HMQC, HMBC and COSY) NMR spectroscopy and mass spectrometry (FABMS, HRFABMS) or in comparison with the literature data in case of known metabolites. Among these isolates, only compounds 1-3 were evaluated for DPPH free radical scavenging potential and enzyme inhibitory activity against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), lipoxygenase (LOX) and metallo-beta-lactamase (IMP-1). The test compound 2 exhibited moderate inhibition of the enzyme lipoxygenase with the IC50 value of 53.5 mu M.

• 出版日期2017-8