Nanoskin (R) Subcutaneous Implant in Guinea Pigs

作者：Kaminagakura Kryscia Natsuaki; Sato Silvana Sue; Sugino Patricia; Santos Daniela Carvalho; Kataki Laryssa; Padovani Carlos Roberto; Basmaji Pierre; Schellini Silvana A^*

来源：Ophthalmic Plastic and Reconstructive Surgery, 2018, 34(2): 136-139.

DOI：10.1097/IOP.0000000000000893

Purpose: To evaluate the suitability of Nanoskin((R)), a biomaterial derived from bacterial cellulose, as an alternate material for repairing the posterior lamellae of the eyelids.
Methods: Forty guinea pigs received a fragment of Nanoskin((R)) subcutaneously in the dorsal region. The animals received Nanoskin((R)) (group 1) or Nanoskin((R)) coated with a gelatin layer (group 2). The animals were observed daily for over 7, 30, 90, or 180 days with the subcutaneous implants in place. The animals were euthanized at a designated time and the Nanoskin((R)) was removed for histologic, morphometric, and transmission electron microscopy evaluation.
Results: The results were similar for both groups. The subcutaneously implanted Nanoskin((R)) resulted in good tissue integration, induced mild inflammation, and was surrounded by a delicate pseudocapsule.
Conclusion: The good tissue integration of Nanoskin((R)) in study indicates that it may be a potential material for application as a substitute of posterior eyelid lamellar tissue. Further clinical studies are required to confirm the preliminary outcomes of this experimental study.

• 出版日期2018-4
• 单位Univ Estadual Paulista