Aminocarbonylation of N-Containing Heterocycles with Aromatic Amines Using Mo(CO)(6)

作者：Mamone Marius; Aziz Jessy; Le Bescont Julie; Piguel Sandrine

来源：Synthesis, 2018, 50(7): 1521-1526.

DOI：10.1055/s-0037-1609152

<jats:p>We describe herein the palladium-catalyzed aminocarbonylation of nitrogen-containing heterocycles with aniline derivatives using molybdenum hexacarbonyl as a CO solid source, expanding the scope of the limited examples. This method is compatible with a variety of substitutions on the aniline moiety. The simple reaction conditions include easily available Pd(dppf)Cl2 catalyst, DBU as base in DMF at 120 °C for 3 hours in sealed tube thereby leading to the isolation of 21 compounds with yields ranging from 18 to 82%. We also show that double aminocarbonylation reactions are possible in satisfactory yields regarding both coupling partners.</jats:p>

• 出版日期2018-4