Microfluidic Synthesis of Cell-Type-Specific Artificial Extracellular Matrix Hydrogels

作者:Allazetta Simone; Hausherr Tanja C; Lutolf Matthias P*
来源:Biomacromolecules, 2013, 14(4): 1122-1131.
DOI:10.1021/bm4000162

摘要

Droplet microfluidic technology is applied for the high-throughput synthesis via Michael-type addition of reactive, micrometer-sized poly(ethylene glycol) (PEG) hydrogels ("microgels") with precisely controlled dimension and physicochemical properties. A versatile chemical scheme is used to modify the reactive PEG microgels with tethered biomolecules to tune their bioactive properties for the bioreactor culture and manipulation of various (stem) cell types.

  • 出版日期2013-4

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