Neutral pi-nucleophile-catalyzed cyanation of aldehydes and ketones

作者：Wang Xiu; Tian Shi Kai^*

来源：Synlett, 2007, (9): 1416-1420.

DOI：10.1055/s-2007-980366

• pi-nucleophile
• cyanosilylation
• cyanocarbonation
• aldehydes
• ketones

1-Methoxy-2-methyl-1-(trimethylsiloxy)propene, a neutral pi-nucleophile, was found to be able to efficiently catalyze the cyanation (cyanosilylation and cyanocarbonation) of various aldehydes and ketones, and this study provided the first illustration of using a neutral pi-nucleophile for the development of synthetically useful organocatalysis.

• 出版日期2007-6-1
• 单位中国科学技术大学