Ultralow sensing limit in optofluidic micro-bottle resonator biosensor by self-referenced differential-mode detection scheme

作者：Zhang, Xingwang; Liu, Liying; Xu, Lei^*

来源：Applied Physics Letters, 2014, 104(3): 033703.

DOI：10.1063/1.4861596

• SURFACE-PLASMON RESONANCE
• WHISPERING-GALLERY-MODE
• NANOPARTICLE DETECTION
• RING LASER
• SENSORS

Biosensors based on optofluidic micro-bottle resonators are demonstrated. A self-referenced sensing scheme, differential mode sensing, is proposed and used to substantially suppress environmental noises and reach an ultralow noise equal detection limit of 10 fg/ml (similar to 0.15 fM) for bovine serum albumin molecules. This sensing scheme has high compatibility with any other microcavity sensors to get lower biosensing limit.

• 出版日期2014-1-20
• 单位复旦大学