科研之友
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摘要
Genetic influences, together with epigenetic components and dietary factors, play a fundamental role in the initiation and progression cif cancer by causing a number of deregulations. Colorectal cancer (CRC) is a disease influenced by dietary factors, for which established genetic and epigenetic alterations have been identified. Within CRC, there are hereditary syndromes that present mutations in the germline hMLH1, and also alterations in the methylation of the promoters. Epigenetics has also been established as a pathway of carcinogenesis. In the present review, we analyzed studies conducted to discern the different pathways leading to established CRC, stressing the importance of identifying factors that may predict CRC at an early si:age, since it is mostly a silent disease observed at the clinical level in advanced stages.
- 出版日期2010-4
