科研之友
微信
新浪微博
Facebook
分享链接
摘要
Efforts have been made in recent years to develop novel functionalisation protocols aimed at imparting multimodality and improved properties to complex carbon-based nanostructures. The incorporation of cleavable bonds to the nanomaterial surface for the controlled release (or exchange) of specific molecules under appropriate chemical and biological settings is relatively unexplored. The design and synthesis of a hetero-bifunctional linker joining a cleavable disulfide moiety for the covalent anchoring of a wide range of thiol end-capped (bio)molecules and a clickable terminal acetylene group is described. The strategy is based on the well-established copper-mediated acetylene-azide coupling reaction between the acetylene linker and single-walled carbon nanotubes decorated with phenylazido pendant arms. As a result, easily post-derivatisable and traceable nanostructured platforms containing a linking group potentially available for a wide range of biological probes are prepared and completely characterised.
- 出版日期2015-4
