Accelerator mass spectrometry (AMS) of the inhibitory effect of six dietary constituents on nicotine-hemoglobin adduction in mice

作者：Cheng Y^*; Wang HF; Sun HF; Li HL; Liu YF; Peng SX; Liu KX; Guo ZY

来源：Journal of Radioanalytical and Nuclear Chemistry, 2005, 264(3): 665-669.

DOI：10.1007/s10967-005-0768-8

Accelerator mass spectrometry (AMS) is an ultra-sensitive method to monitor and trace the environmental exposure levels of C-14-labeled molecules in vivo. Nicotine [3-(1-methyl-2-pyrrolidinyl)-pyridine], a major alkaloid in tobacco products, has proven to be a potential genotoxic compound. Using C-14-labeled nicotine and AMS, we have investigated the inhibitory effect of curcumin, garlic squeeze, grapeseed extract, tea polyphenols, vitamin C and vitamin E, respectively, on nicotine-hemoglobin (Hb) adduction in vivo. The results demonstrated that these dietary constituents induced remarkable decrease of nicotine-Hb adducts. The inhibitory fact may afford an important clue of the chemoprevention of the potential nicotine-induced carcinogenesis.

• 出版日期2005-5
• 单位北京大学